This October, guitarist Warren Haynes, bassist George Porter Jr., drummer Joe Russo and keyboardist John Medeski will once again team up at The Capitol Theatre in Port Chester, NY, for “One Night Only… Again!”

All proceeds from the performance, set for Oct. 19 at The Cap, will go to benefit DEBRA of America, an NYC-based non-profit that helps fund research on the condition dystrophic epidermolysis bullosa. Tickets go on sale this Friday, Aug. 2, at noon ET here.

Haynes, Porter, Russo and Medeski first teamed up for “One Night Only” at The Cap last October, when they also welcomed saxophonist Skerik for several songs throughout the two-set affair, which included blues standards, instrumental jams, covers and more.

Below, watch the collective take on Jimi Hendrix’s version of “Hey Joe,” and check out a photo gallery from the first One Night Only here.